8-Amino-5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one → 8-[5-Chloro-4-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-5,5-dimethyl-1,3,4,5-tetrahydro-1-benzazepin-2-one

HRID 178874Notes

Reaction equation

HRID 178874 reaction equation
[Cl:16][c:17]1[n:18][cH:19][c:20]([Cl:38])[c:21]([NH:23][c:24]2[c:25]([O:36][CH3:37])[cH:26][c:27]([N:30]3[CH2:31][CH2:32][O:33][CH2:34][CH2:35]3)[cH:28][cH:29]2)[n:22]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:15]1)[NH:7][C:8](=[O:14])[CH2:9][CH2:10][C:11]2([CH3:12])[CH3:13]>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:15]1)[NH:7][C:8](=[O:14])[CH2:9][CH2:10][C:11]2([CH3:12])[CH3:13])[c:17]1[n:18][cH:19][c:20]([Cl:38])[c:21]([NH:23][c:24]2[c:25]([O:36][CH3:37])[cH:26][c:27]([N:30]3[CH2:31][CH2:32][O:33][CH2:34][CH2:35]3)[cH:28][cH:29]2)[n:22]1

Participants

3

Reactant 2

HCID 574160628-Amino-5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-oneHCID 86633851(2,5-Dichloropyrimidin-4-yl)-(2-methoxy-4-morpholin-4-yl-phenyl)-amine

Product 1

HCID 672640568-[5-Chloro-4-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-5,5-dimethyl-1,3,4,5-tetrahydro-1-benzazepin-2-one

Sources & evidence

ORD record
ord-0259294b3aaf43c5aea526f945b98489
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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