Allyl bromide → HCID 13885860, compound

Participants

Reaction Steps

A slurry of sodium hydride (168 mg, 4.2 mmole, 60% in mineral oil dispersion) in 5 ml of dry tetrahydrofuran at 0° C. under argon was treated dropwise with 1,4-dihydro-2-[[(4-methoxyphenyl)methyl]thio]-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid, methyl ester in 15 ml of dry tetrahydrofuran. After an additional 10 minutes at 0° C., allyl bromide was added and the reaction mixture was allowed to warm to room temperature overnight.

Provenance & Evidence