1,2-Dichloroethane → HCID 20190397, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carboxylic acid (8.8 g) in a mixture of thionyl chloride (6.25 cc), dimethylformamide (0.05 cc) and 1,2dichloroethane (100 cc) is heated under reflux with stirring for 2 hours and 30 minutes. The reaction mixture is cooled to a temperature of about 20° C. and concentrated to dryness under reduced pressure (20 mm Hg; 2.7 kPa) at a temperature of about 60° C. The residue obtained is suspended in cyclohexane (150 cc) and the solvent is evaporated off under reduced pressure (20 mm Hg; 2.7 kPa) at a temperature of about 60° C. The same procedure is repeated twice. 7- Chloroformyl-5-(3-pyridyl)-pyrrolo[1,2-c]thiazole hydrochloride (10 g) is thus obtained in the form of cream crystals melting at 220° C.

Provenance & Evidence