Triethylamine → HCID 18600878, compound

Participants

Reaction Steps

To a mixture of 1.10 g of (3s, 4RS)-4-cyano-3-tritylamino-2-azetidinone, 0.50 g of triethylamine and 20 ml of methylene chloride is added 0.56 g of tert-butyldimethylsilyl chloride under ice-cooling and stirring. The mixture is stirred at room temperature (approx. 25° C.) for 30 minutes and the reaction mixture is concentrated under reduced pressure. The residue is chromatographed on a silicagel column [eluant: ethyl acetate-n-hexane (1:3)] to give 0.64 g of (3s, 4RS)-1-tert-butyldimethylsilyl-4-cyano-3-tritylamino-2-azetidinone.

Provenance & Evidence