Triphenylphosphine → HCID 13578044, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1550 mg of 4-nitrobenzyl 2-(4-allylsulphinylazetidin-2-on-1-yl)-3-phenoxy-3-thioxo-propanate (containing 10% pivalic acid), 808 mg of triphenylphosphine and dioxan was heated under an argon atmosphere at 110° C. for 15 minutes. The mixture was evaporated in vacuo to dryness, and the resulting oil was chromatographed on silica gel. Elution with ethyl acetate-hexane mixtures afforded 219 mg of a solid. This was taken up in ethyl acetate and extracted with sodium bicarbonate to afford, after evaporation in vacuo, 192 mg of the title compound (11% of the theoretical yield).

Provenance & Evidence