HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Acetylbenzothiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | HCID 21584106 | HCID 21584106 | — |
| Catalyst | Copper | HCID 23978 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Acetylbenzothiophene | HCID 89805 | 70% |
Reaction Steps
The amino ester (2) was converted to the diazonium salt and reduced by boiling in ethanol containing finely divided copper to give the pure ester (3). Hydrolysis of the ester with aqueous ethanolic KOH followed by acidification with 5M HCl, gave the acid (4) in approximately 70% yield. The acid was converted to the corresponding acid chloride (5) by reaction with SOCl2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04685783 |
| Source dataset | uspto-grants-1987_08 |
| ORD ID | ord-68c35c50649b4a169b7dad29368e7ca8 |
| Source note | uspto-grants-1987_08 |