HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-[(4-Chlorophenylthio)methylamino]-4-methoxy-6-methylpyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | p-Chlorothiophenol | HCID 7815 | — |
| Reactant | 4-Methoxy-6-methylpyrimidin-2-amine | HCID 587236 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[(4-Chlorophenylthio)methylamino]-4-methoxy-6-methylpyrimidine | HCID 23043234 | — |
Reaction Steps
A mixture of 13.99 g of 2-amino-4-methoxy-6-methylpyrimidine (0.1 mole), 14.8 g of 4-chlorothiophenol (0.1 mole), 9.4 g of aqueous 35% formaldehyde (0.11 mole) and 1 g of acetic acid are heated under reflux for 1 hour in 100 ml of methanol. The resultant solution is clarified by filtration, diluted with 150 ml of toluene and then the solvent is removed in a rotary evaporator. The residue crystallises after standing for some time. The melting point is 78°-82° after recrystallisation from hexane. The yield is 24 g (81% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04685961 |
| Source dataset | uspto-grants-1987_08 |
| ORD ID | ord-3873046c49ec48d7830f08215588ea91 |
| Source note | uspto-grants-1987_08 |