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Acetic Acid → 4-Methoxy-6-methyl-2-(1,2,4-triazol-1-ylmethylamino)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | 1H-1,2,4-Triazole | HCID 9257 | — |
| 反応物 | 4-Methoxy-6-methylpyrimidin-2-amine | HCID 587236 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-Methoxy-6-methyl-2-(1,2,4-triazol-1-ylmethylamino)pyrimidine | HCID 23043232 | — |
反応手順
With stirring, a mixture of 13.9 g (0.1 mole) of 2-amino-4-methoxy-6-methylpyrimidine, 7 g (0.1 mole) of 1,2,4,-triazole, 9.4 g (0.11 mole) of aqueous 35% formaldehyde and 1 g of acetic acid in 100 ml of methanol is refluxed for 11/2 hours. First a clear solution forms, from which the reaction product precipitates in crystalline form after a time. After the reaction mixture has cooled, the crystalline title compound is filtered with suction and dried. Yield: 14 g. Melting point: 191°-193° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04685961 |
| 出典データセット | uspto-grants-1987_08 |
| ORD ID | ord-e6ac12f889244b25b87f4427cb95a90e |
| 出典メモ | uspto-grants-1987_08 |