Diethyl Ether → HCID 13821866, compound

Participants

Reaction Steps

A solution of 3-dimethylaminomethyl-2-methylimidazo[2,1-a]isoquinoline (7.7 g) in tetrahydrofuran (20 ml) was added dropwise to a solution of dimethyl sulfate (15 ml) in tetrahydrofuran (40 ml) with ice-cooling and stirring, and the mixture was stirred for 2 hours under the same conditions. To the reaction mixture was added diethyl ether (60 ml) and stirred with ice-cooling for 1 hour. The resulting precipitates were collected by filtration, washed with diethyl ether and recrystallized from ethanol to give 2-methyl-3-trimethylammoniomethylimidazo[2,1-a]isoquinoline methylsulfate (10 g).

Provenance & Evidence