HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Nitro-4-benzoylphenylacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl 2-nitro-4-benzoylphenylmalonate | HCID 13408230 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Nitro-4-benzoylphenylacetic acid | HCID 13770536 | 95% |
Reaction Steps
A mixture of 14 g. (36.3 mmoles) of diethyl 2-nitro-4-benzoylphenylmalonate, 300 ml. of 4N hydrochloric acid and 300 ml. of dioxane was heated to reflux for 10 hours. The reaction mixture was concentrated in vacuo and the crude product was triturated with hot methylene chloride, 9.88 g. (95% yield), m.p. 168°-170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04686224 |
| Source dataset | uspto-grants-1987_08 |
| ORD ID | ord-abaea9c2d3f2432c870e6577b3d1cda8 |
| Source note | uspto-grants-1987_08 |