反应详情

2,3-Dichloro-6-fluorobenzaldehyde (1.44 g, 7.5 mmoles), methyl 4-fluoro-3-oxobutanoate (1.0 g, 7.5 mmoles) and 1-methylethyl 3-amino-2-butenoate (1.06 g, 7.5 mmoles) were heated at 90° under nitrogen with stirring for 2.5 hours. The cooled reaction mixture was chromatographed on silica eluting with ethyl acetate/methylene chloride mixtures. The title compound (1.1 g) was obtained by crystallisation from a petroleum ether (60°-80°)/2-propanol mixture mp 129°-31°.

1. customThe cooled reaction mixture
2. customwas chromatographed on silica eluting with ethyl acetate/methylene chloride mixtures