Dimethylamine → HCID 20189346, compound

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Reaction Steps

Thionyl chloride (0.05 ml) was added to a solution of 3,5-diethyl 1,4-dihydro-6-methyl-4-(3-nitrophenyl)-2,3,5-pyridinetricarboxylate (0.25 g, 0.62 mmoles) in methylene chloride (10 ml) containing dimethylformamide (1 drop). After 2 hours at room temperature further thionyl chloride (0.05 ml) was added and the solution was refluxed for 30 mins. After cooling to room temperature 10% dimethylamine in benzene (1 ml) was added and the mixture stirred for 30 mins. The solvent was evaporated and the residue dissolved in dilute hydrochloric acid and ether. The organic extract was washed with brine, dried (Na2SO4) and the solvent removed in vacuo to leave the title compound (0.2 g). M+ 431; nmr (CDCl3) δ 5.12 (s,H), 3.05 (s,3H), 2.95 (s,3H).

Provenance & Evidence