反应详情

温度

75 °C

114 g of (+)-1-[4-methoxy-2-pyridyl]-ethyl acetate are added dropwise at 70° C. to 220 ml of 4N sodium hydroxide solution. The mixture is then stirred for a further 2 h at 75° C., cooled and extracted with four times 200 ml of dichloromethane. The organic phase is washed with 2N sodium hydroxide solution and water, dried over sodium sulphate and concentrated to dryness. After thorough stirring with 250 ml of diisopropyl ether, this gives 64 g (72%) of the title compound of m.p. 92° C.

1. temperaturecooled
2. extractionextracted with four times 200 ml of dichloromethane
3. washThe organic phase is washed with 2N sodium hydroxide solution and water
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated to dryness
6. stirringAfter thorough stirring with 250 ml of diisopropyl ether