反应详情

温度

90 °C

171 g of 2-ethyl-4-methoxy-pyridine N-oxide are added dropwise within 3 h to 312 ml of acetic anhydride heated to 90° C., in such a way that the internal temperature does not exceed 115° C. The mixture is then left to stand for a further 2.5 h at 100° C., and excess acetic anhydride is stripped off. Distillation of the residue gives 171 g (78%) of the title compound of b.p. 100° C./1 Pa.

1. customdoes not exceed 115° C
2. waitThe mixture is then left
3. distillationDistillation of the residue