Nitric Acid → HCID 20189570, compound

Participants

Reaction Steps

50 g of 2,3-dimethoxyphenol are reacted analogously to Example B12a with 80 g of potassium hydroxide and chlorodifluoromethane in dioxane/water. The mixture is extracted with diisopropyl ether by shaking, the extract is washed with sodium hydroxide solution and 35 g of a product (b.p. 70°-74° C./0.3 mbar) are obtained which is reacted with 100% nitric acid analogously to Example B7b. The reaction product is subjected to chromatography on a silica gel column with cyclohexane/ethyl acetate (3:2), after which 1-difluoromethoxy-2,3-dimethoxy-5-nitrobenzene (m.p. 72°-73° C.) is isolated in 48% yield.

Provenance & Evidence