1-Chloro-4-(chloromethyl)benzene → 4-(4-Chlorophenyl)-3,3-dimethylbutan-2-one

Participants

Reaction Conditions

Reaction Steps

254.4 g (4 mols) of powdered technical grade potassium hydroxide (88% strength) are suspended in 1 liter of toluene, 40 g of tetrabutylammonium bromide are added, and a mixture of 644 g (4 mols) of 4-chlorobenzyl chloride and 430 g (5 mols) of methyl isopropyl ketone is then slowly added dropwise at 85° C. To complete the reaction, the mixture is stirred for a further 3 hours at 85° C. after the dropwise addition is complete. After the mixture has been cooled, the potassium chloride is filtered off and the filtrate is washed neutral. 732.5 g (87% of theory) of 1-(4-chlorophenyl)-2,2-dimethylbutan-3-one of boiling point 87°-90° C./0.05 mbar are obtained by fractional distillation.

Provenance & Evidence