Toluene → HCID 12591156, compound

Participants

Reaction Conditions

Reaction Steps

70 g (1.1 mols) of powdered technical grade potassium hydroxide (88% strength) and 10 g of tetrabutylammonium bromide in 250 ml of toluene are initially introduced. A mixture if 119 g (1 mol) of propargyl bromide and 103.2 g (1.2 mols) of methyl isopropyl ketone is then added dropwise so that the temperature does not exceed 45° C. The mixture is stirred for a further 12 hours at 45° C., and is worked up according to Example 1. 67 g (54% of theory) of 4,4-dimethyl-hex-1-in-5-one of boiling point 55° C./12 mbar are obtained.

Provenance & Evidence