Bromine → 1-Bromo-3,3-dimethyl-4-phenylbutan-2-one

HRID 1789068Notes

Reaction equation

HRID 1789068 reaction equation
[CH3:1][C:2]([CH3:13])([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3](=[O:5])[CH3:4].[Br:14]Br>C(Cl)(Cl)Cl>[Br:14][CH2:4][C:3](=[O:5])[C:2]([CH3:13])([CH3:1])[CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 836703,3-Dimethyl-4-phenylbutan-2-one

Product 1

HCID 132100511-Bromo-3,3-dimethyl-4-phenylbutan-2-oneYield 100%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

100 g (0.57 mol) of 3,3-dimethyl-4-phenylbutan-2-one (Example 5) are dissolved in 0.8 liter of chloroform, and 29 ml (91.9 g; 1.14 mols) of bromine are added slowly at room temperature. The mixture is stirred for a further hour at room temperature and is concentrated. 145.5 g (quantitative) of 1-bromo-3,3-dimethyl-4-phenylbutan-2-one are obtained, and this directly reacted further, without isolation. ##STR24##

Workup

  1. concentrationis concentrated

Sources & evidence

ORD record
ord-2f4f64a7a9604d9cb15c5894dbbdf971
Source dataset
uspto-grants-1987_08
Patent number
US04686291

Reaction notes

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