Sulfuric Acid → Methyl 5-amino-2-ethoxy-4-nitrobenzoate

Participants

Reaction Steps

A suspension of 1 5 g of ethyl 5-acetylamino-2-ethoxy-4-nitrobenzoate in 50 ml of 5 % (v/v) sulfuric acid methanolic solution was refluxed for 4 hours After cooling, the reaction solution was poured into an ice water, the resulting crystals were collected by filtration and recrystallized from methanol to give the title compound, m.p. 156°-157° C., yield of 1.01 g.

Provenance & Evidence