Hydrochloric Acid → HCID 13912874, compound

Participants

Reaction Steps

To a suspension of 13.57 g of methyl 5-amino-2-methoxy-4-nitrobenzoate in 250 ml of dioxane was added a solution of 4.36 g of potassium hydroxide in 25 ml of water, and the mixture was refluxed for 4 hours. To the reaction solution was added 7 ml of concentrated hydrochloric acid. The solvent was evaporated under reduced pressure, and the residue, after addition of dioxane, was refluxed for an hour. The insoluble was removed by filtration, and the filtrate was allowed to stand to give the title compound, m.p. 252°-255° C., yield of 10.99 g.

Provenance & Evidence