Pyridine → HCID 13587813, compound

Participants

Reaction Steps

4-Hydroxy-4'-fluorobiphenyl (2.1 g, 0.012 mol) was dissolved in pyridine (10 ml), and to the solution was added β-(4-hexyloxyphenyl)propionic acid chloride (3.0 g, 0.01 mol) with sufficient shaking, followed by allowing the resulting reaction solution to stand overnight, thereafter pouring it in water (100 ml), extracting the resulting oily material with toluene (100 ml), washing the toluene layer with 6N-HCl and then with 2N-NaOH, further washing with water till the washing liquid became neutral, filtering, distilling off toluene under reduced pressure, and recrystallizing residual crystals from ethanol to obtain the objective 4'-fluoro-4-biphenylyl α-methyl-β-(4-hexyloxyphenyl)propionate (2.1 g, yield 48%). m.p.: 78.4°-79.5° C. N-I point: 38.1° C.

Provenance & Evidence