3-(Dimethylamino)-1-phenyl-1-propanone → alpha-(1-Methyl-2-pyrrolidinyl)acetophenone 2,4,6-triisopropylbenzenesulphonylhydrazone hydrochloride

Participants

Reaction Steps

α-(1-Methyl-2-pyrrolidinyl)acetophenone 2,4,6-triisopropylbenzenesulphonylhydrazone can be prepared by a method similar to that described in Example 22 for the preparation of β-dimethylaminopropiophenone, 2,4,6-triisopropylbenzenesulphonylhydrazone, but starting from 2,4,6-triisopropylbenzenesulphonylhydrazine (30.6 g) and α-(1-methyl-2-pyrrolidinyl)acetophenone hydrochloride (28.3 g). In this way, α-(1-methyl-2-pyrrolidinyl)acetophenone 2,4,6-triisopropylbenzenesulphonylhydrazone hydrochloride (31.1 g) is obtained in the form of a white solid melting at 210° C.

Provenance & Evidence