HCID 21284778, compound → HCID 54483223, compound

HRID 1789160Notes

Reaction equation

HRID 1789160 reaction equation
[NH2:1][CH2:2][C:3]1[CH:19]=[CH:18][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][C:15](O)=[O:16])[N:10]=[N:9]2)=[CH:5][CH:4]=1.C(C1C=CC(CN2C=C(C=CC(O)=O)N=N2)=CC=1)#N>>[C:2]([C:3]1[CH:19]=[CH:18][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([CH:13]=[CH:14][CH:15]=[O:16])[N:10]=[N:9]2)=[CH:5][CH:4]=1)#[N:1]

Participants

3

Reactant 2

HCID 21284778HCID 21284778, compoundHCID 54302536HCID 54302536, compound

Product 1

HCID 54483223HCID 54483223, compoundYield 41%

Procedure

3-[1-(4-aminomethylbenzyl)-1,2,3-triazol-4-yl]-propionic acid (m.p. 207°-210° C.; prepared by catalytic hydrogenation of 3-[1-(4-cyanobenzyl)-1,2,3-triazol-4-yl]-acrylic acid (m.p. 168°-170° C.) which is obtained by oxidation of the corresponding 3-[1-(4-cyanobenzyl)-1,2,3-triazol-4-yl]-acrolein (m.p. 152°-155° C.)):

Sources & evidence

ORD record
ord-4819b5e5895e4960952ecc255abd55df
Source dataset
uspto-grants-1987_08
Patent number
US04687767

Reaction notes

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