Benzimidazole → HCID 22394120, compound

HRID 1789213Notes

Reaction equation

[OH2:1].[CH3:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:13]3[CH:14]=[CH:15][CH:16]=[C:17]([CH2:18][S:19][C:20]4[NH:24][C:23]5[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=5[N:21]=4)[C:12]3=[N:11][CH:10]=2)=[CH:5][CH:4]=1.CC1C=CC(C2N3C=CC=C(CSC4NC5C=CC=CC=5N=4)C3=NC=2)=CC=1.N1C2C=CC=CC=2N=C1>>[CH3:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:13]3[CH:14]=[CH:15][CH:16]=[C:17]([CH2:18][S:19]([C:20]4[NH:21][C:22]5[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=5[N:24]=4)=[O:1])[C:12]3=[N:11][CH:10]=2)=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 5798Benzimidazole

HCID 70434701HCID 70434701, compound

Product 1

HCID 22394120HCID 22394120, compoundYield 56%

Procedure

The title compound (801 mg) was prepared by the method of Example 2 using 1.38 g (3.7 mmole) of 2-[[[3-(4-methylphenyl)imidazo[1,2-a]pyridin-8-yl]methyl]thio]-1H-benzimidazole hemihydrate (see Example 53) instead of 2-[(imidazo[1,2-a]pyridin-8-yl]methyl)thio]-1H-benzimidazole. Structure assignment was supported by the nmr and infrared spectra and by elemental analysis.

Sources & evidence

ORD record: ord-86536fe8661e486a88a22adbeb7d5c2f
Source dataset: uspto-grants-1987_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04687775

Reaction notes

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