Ethyl 3-oxo-3-(1,3-thiazol-2-ylamino)propanoate → Ethyl 2-[(2-chloro-1-oxo-3,3-dimethylbutyl)-amino]-beta-oxo-alpha-[(2-thiazolylamino)-carbonyl]-3-(trifluoromethyl)-benzene-propanoate

Participants

Reaction Steps

Using the procedure of Step A of Example 4, 7.7 g of ethyl 3-(2-thiazolylamino)-3-oxo-propanoate and 10.55 g of 2-(1-chloro-2,2-dimethylpropyl)-8-trifluoromethyl-4H-3,1-benzoxazine-4-one [prepared according to the process described in the European Pat. No. 0040573] were reacted to obtain 15.6 g of ethyl 2-[(2-chloro-1-oxo-3,3-dimethylbutyl)-amino]-β-oxo-α-[(2-thiazolylamino)-carbonyl]-3-(trifluoromethyl)-benzene-propanoate melting at 180° C.

Provenance & Evidence