Tetrahydrofuran → 1-Morpholino-2-cyano-3-(2',3'-dichlorophenyl)-4-nitro-but-1-ene

Participants

Reaction Steps

5.0 g of 1-(2',3'-dichlorophenyl)-2-nitroethylene, 3.18 g of 3-morpholinoacrylonitrile and 30 ml of tetrahydrofuran (abs.) are refluxed for 24 hours, and the reaction solution is subsequently concentrated by evaporation. The resulting residue, dissolved in toluene/ethyl acetate (2:1 V/V), is chromatographed through silica gel, and from the eluate is thus obtained the finished product, m.p. 74°-77° C. IR (CHCl3) in cm-1 ; 2200 (CN), 1630 (C=C), 1560 (NO2). NMR (CDCl3) in ppm: 4.5 (m, 4H); 4.7 (m, 4H); 4.8 (ABX, 3H); 6.60 (s, 1H); 7.2-7.5 (m, 3H).

Provenance & Evidence