p-Toluenesulfonic acid → HCID 13924103, compound

Participants

Reaction Steps

(3S)-2,2-dimethyl-3-hydroxycyclohexanone (3) (5.12 g, 36.0 mmoles) and dihydropyran (5.00 g., 59.0 mmoles) were dissolved in dry methylene dichloride (90 ml). The solution was cooled in an ice bath, and p-toluenesulfonic acid (50 mg) was added. The resulting mixture was stirred at room temperature for 2 hours. After the reaction, a saturated aqueous solution of sodium hydrogencarbonate was washed with an aqueous solution of sodium chloride and dried over magnesium sulfate. The product was filtered, concentrated, and purified by distillation. Amount yielded 8.14 g (yield 99.9%).

Provenance & Evidence