反应详情

To a solution of 46.5 g of 2-(2-chloroethyloxy)benzaldehyde and 33.2 g of ethylene glycol in 500 ml of benzene in added 0.5 ml of 85% phosphoric acid, and the mixture is refluxed with stirring for about 18 hours while removing the produced water. After the reaction, the reaction mixture is cooled with ice and is made alkaline with saturated sodium bicarbonate solution to separate into two layers. The benzene layer is taken, washed with saturated saline solution, dried and then distilled to remove the solvent. The crude product thus obtained is distilled to give 56 g of 2-(2-chloroethyloxy)benzaldehyde ethyleneacetal (yield: 97%) as a colorless oil. b.p. 130°-135° C./0.3 mmHg.

1. customwhile removing the produced water
2. customAfter the reaction
3. temperaturethe reaction mixture is cooled with ice
4. customto separate into two layers
5. washwashed with saturated saline solution
6. customdried
7. distillationdistilled
8. customto remove the solvent
9. customThe crude product thus obtained
10. distillationis distilled