反应详情

2.21 g of sodium hydroxide are added to a solution of 5.75 g of cysteamine hydrochloride in 200 ml of ethanol, and a solution of 14.28 g of 2-[2-(4-phenylpiperazin-1-yl)ethyloxy]benzaldehyde in 100 ml of ethanol is added thereto. After the mixture is stirred at room temperature for 2 hours, the mixture is concentrated under reduced pressure to remove solvent. The residue is dissolved in ethyl acetate, and the solution is washed with water, dried and then concentrated under reduced pressure to remove solvent. The residue is recrystallized from ether. 15.54 g of 2-{2-[2-(4-phenylpiperazin-1-yl)ethyloxy]phenyl}thiazolidine are obtained.

1. concentrationthe mixture is concentrated under reduced pressure
2. customto remove solvent
3. dissolutionThe residue is dissolved in ethyl acetate
4. washthe solution is washed with water
5. customdried
6. concentrationconcentrated under reduced pressure
7. customto remove solvent
8. customThe residue is recrystallized from ether