2-Acetylbenzofuran → 1-(1-Benzofuran-2-Yl)-2-Bromoethan-1-One

HRID 1789389Notes

Reaction equation

HRID 1789389 reaction equation
[CH3:1][C:2]([C:4]1[O:5][C:6]2[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)=[O:3].[Br:13]Br>C(Cl)Cl>[O:5]1[C:6]2[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=[C:4]1[C:2](=[O:3])[CH2:1][Br:13]

Participants

4

Reactant 2

HCID 154352-AcetylbenzofuranHCID 24408Bromine

Product 1

HCID 27354511-(1-Benzofuran-2-Yl)-2-Bromoethan-1-One

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Benzofuran-2-yl methyl ketone (20 g) is dissolved in 100 ml of methylene chloride and 3.2 ml of bromine in methylene chloride is added at 5°-10° C. Then the reaction mixture is stirred at +15° C. for 2 hours. Then it is washed with water, with diluted sodium bicarbonate solution and again with water. The organic phase is dried and evaporated to dryness to give crude 1-(benzofuran-2-yl)-2-bromoethanone.

Workup

  1. washThen it is washed with water, with diluted sodium bicarbonate solution and again with water
  2. customThe organic phase is dried
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-831b47ccaa75402fb592e9fa15e798c2
Source dataset
uspto-grants-1987_08
Patent number
US04689339

Reaction notes

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