HCID 15338838, compound → HCID 18609504, compound

HRID 1789398Notes

Reaction equation

HRID 1789398 reaction equation
[CH3:1][CH:2]1[C:10]2[C:5](=[C:6]([CH3:11])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:12]([OH:14])=[O:13]>C(O)C.O.[Pd]>[CH3:1][C@@H:2]1[C:10]2[C:5](=[C:6]([CH3:11])[CH:7]=[CH:8][CH:9]=2)[CH2:4][C@@H:3]1[C:12]([OH:14])=[O:13]

Participants

4

Reactant 1

HCID 15338838HCID 15338838, compound

Product 1

HCID 18609504HCID 18609504, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 19096565Water ethanolSolvent

Procedure

1,4-Dimethyl-indene-2-carboxylic acid (35.5 g) is hydrogenated in ethanol-water (700 ml-70 ml) over 10% palladium on carbon at ambient temperature. After filtration ethanol is evaporated. Water is added and the precipitated cis-2,3-dihydro-1,4-dimethyl-1H-indene-2-carboxylic acid is filrated. Yield 33.3 g, 93% M.p. 132°-135° C.

Workup

  1. filtrationAfter filtration ethanol
  2. customis evaporated
  3. additionWater is added

Sources & evidence

ORD record
ord-28e41baf097a49e6ac6270dddced12dd
Source dataset
uspto-grants-1987_08
Patent number
US04689339

Reaction notes

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