Ethylamine → HCID 178464573, compound

HRID 1789408Notes

Reaction equation

HRID 1789408 reaction equation
[C:1]([N:3]=[C:4](SC)[NH:5][CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1)#[N:2].[CH2:18]([NH2:20])[CH3:19]>C(O)C>[C:1]([N:3]=[C:4]([NH:5][CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1)[NH:20][CH2:18][CH3:19])#[N:2]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 178503884HCID 178503884, compound

Product 1

HCID 178464573HCID 178464573, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 6.13 g of N'-cyano-N-(1,2,3,4-tetrahydro-1-naphthyl)-S-methylisothiourea and 10 ml of 70% aqueous ethylamine in 90 ml of ethanol was heated at reflux with stirring for 20 hours. The reaction mixture was cooled in a refrigerator to give 2.44 g of N"-cyano-N-ethyl-N'-(1,2,3,4-tetrahydro-1-naphthyl)guanidine as a white, crystalline solid, mp 152°-153.5° C.

Workup

  1. temperatureat reflux
  2. temperatureThe reaction mixture was cooled in a refrigerator

Sources & evidence

ORD record
ord-633630798e4d4a5bb72b060b5562efd4
Source dataset
uspto-grants-1987_08
Patent number
US04689348

Reaction notes

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