Triethyl orthoacetate → 1-benzyl-2-methyl-1H-imidazo[4,5-c]quinoline hydrate

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Reaction Steps

Using the method of Example 31, 3-amino-4-(benzylamino)quinoline (from Example 124, Part B) was reacted with triethyl orthoacetate and acetic acid to provide 1-benzyl-2-methyl-1H-imidazo[4,5-c]quinoline hydrate, m.p. 145°-147° C. Analysis: Calculated for C18H15N3 ·2.25H2O: % C, 68.9; % H, 6.3; % N, 13.4; Found: % C, 69.2; % H, 6.0; % N, 13.4.

Provenance & Evidence