反应详情

A mixture of 5.6 g (0.016 mole) of 4-chloro-1-isobutyl-2-phenyl-1H-imidazo[4,5-c]quinoline and 30 ml of a 20% mixture of ammonia in methanol was placed in a metal bomb and heated at 145°-150° C. for about 6 hours. After cooling, the solid was separated by filtration, washed with methanol and dried to provide 3.8 g of crude product. Recrystallization of the solid from ethanol provided 2.4 g of colorless 1-isobutyl-2-phenyl-1H-imidazo[4,5-c]quinolin-4-amine hydrate, melting point 194°-205° C. Analysis: Calculated for C20H20N4.1/2H2O: % C, 73.8; % H, 6.5: % N, 17.2. Found: % C, 73.6; % H, 6.2: % N, 17.0

1. temperatureheated at 145°-150° C. for about 6 hours
2. temperatureAfter cooling
3. customthe solid was separated by filtration
4. washwashed with methanol
5. customdried
6. customto provide 3.8 g of crude product
7. customRecrystallization of the solid from ethanol