反应详情

Heat a mixture of 6.23 g (0.017 mole) 4-methylbenzenesulfonic acid 4-(4-acetylaminophenyl)butyl ester and 2.9 g (0.017 mole) 1-heptyl-1H-imidazole to 80° C., for 5 hours, following the reaction by thin-layer chromatography on silica gel (acetonitrile: ammonium hydroxide, 90:10). At the completion of the reaction, triturate the cooled resultant material with petroleum ether. Recrystallize the material from 25 ml hot methyl ethyl ketone with hot filtration, chill and seed to obtain the title compound.

1. temperatureHeat
2. customthe reaction by thin-layer chromatography on silica gel (acetonitrile: ammonium hydroxide, 90:10)
3. customAt the completion of the reaction
4. customtriturate the
5. temperaturecooled resultant material with petroleum ether
6. customRecrystallize the material from 25 ml hot methyl ethyl ketone
7. filtrationwith hot filtration
8. temperaturechill