1-Methylimidazole → HCID 178480862, compound

HRID 1789474Notes

Reaction equation

HRID 1789474 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11]Cl)=[CH:4][CH:3]=1.[CH3:13][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>>[Cl-:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N+:16]2[CH:17]=[CH:18][N:14]([CH3:13])[CH:15]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 13901-MethylimidazoleHCID 200827321-Chloro-4-(4-chlorobutyl)benzene

Product 1

HCID 178480862HCID 178480862, compound

Procedure

Combine 6.1 g (0.03 mole) 1-chloro-4-(4-chlorobutyl)benzene with 2.5 g (0.03 mole) 1-methyl-1H-imidazole and heat at 120° C., following the course of the reaction by thin-layer chromatography on silica gel (methanol:1M sodium chloride, 95:5). At the completion of the reaction, cool and triturate with ether, collect the solid and recrystallize from 50 ml hot acetone to obtain the title compound.

Workup

  1. customthe course of the reaction by thin-layer chromatography on silica gel (methanol:1M sodium chloride, 95:5)
  2. customAt the completion of the reaction
  3. temperaturecool
  4. customtriturate with ether
  5. customcollect the solid
  6. customrecrystallize from 50 ml hot acetone

Sources & evidence

ORD record
ord-902acbb33e034967a63b13b5cc75a2c2
Source dataset
uspto-grants-1987_08
Patent number
US04689341

Reaction notes

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