反应详情

Heat a mixture of 30.83 g (0.097 mole) of (±)-1-[2-hydroxy-2-[4-((methylsulfonyl)amino)phenyl]ethyl-1H-imidazole hydrochloride and 5.24 g (0.097 mole) of sodium methylate in 100 mL of methanol and filter hot through 300 g of alumina (Fisher, neutral, activity III). Wash the alumina with 20% methanol in methylene chloride (200 mL). Concentrate the filtrate in vacuo to afford the title compound.

1. temperatureHeat
2. filtrationfilter hot through 300 g of alumina (Fisher, neutral, activity III)
3. washWash the alumina with 20% methanol in methylene chloride (200 mL)
4. concentrationConcentrate the filtrate in vacuo