HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenyl isothiocyanate → N-[(1-acetyl-4-piperidinyl)methyl]-N'-(4-chlorophenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| Reactant | 1-(4-(Aminomethyl)piperidin-1-yl)ethan-1-one | HCID 12687022 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[(1-acetyl-4-piperidinyl)methyl]-N'-(4-chlorophenyl)thiourea | HCID 14048939 | 99.7% |
Reaction Steps
A mixture of 3.1 parts of 1-acetyl-4-piperidinemethanamine, 3.4 parts of 1-chloro-4-isothiocyanatobenzene and 90 parts of tetrahydrofuran was stirred for 3 hours at room temperature. The reaction mixture was evaporated, yielding 6.5 parts (99.7%) of N-[(1-acetyl-4-piperidinyl)methyl]-N'-(4-chlorophenyl)thiourea as a residue (intermediate 14).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04689330 |
| Source dataset | uspto-grants-1987_08 |
| ORD ID | ord-b8d469ec02df442d9a9d4e4733d2e923 |
| Source note | uspto-grants-1987_08 |