Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | 4-(2-Methyl-1,3-dioxolan-2-yl)piperidine | HCID 21241583 | — |
| Reactant | HCID 131715235 | HCID 131715235 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 21241621 | HCID 21241621 | 100% |
Reaction Steps
A mixture of 22.5 parts of 2,3-dihydro-1,4-benzodioxin-2-methanol 4-methylbenzenesulfonate (ester), 11.1 parts of 4-(2-methyl-1,3-dioxolan-2-yl)piperidine, 15 parts of sodium carbonate and 135 parts of N,N-dimethylacetamide was stirred overnight at 75° C. Water was added. The product was extracted with 4-methyl-2-pentanone. The extract was dried, filtered and evaporated, yielding 20.6 parts (100%) of 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-4-(2-methyl-1,3-dioxolan-2-yl)piperidine as an oily residue (intermediate 86).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04689330 |
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| Source dataset | uspto-grants-1987_08 |
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| ORD ID | ord-ce4481d3c1e949b698e956653885160d |
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| Source note | uspto-grants-1987_08 |
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