Acetophenone → Phenylpyruvic acid

Participants

Reaction Steps

Into a stainless steel-made autoclave of 135 ml capacity were introduced 25 ml of water, 6.2 g of calcium hydroxide, 5.1 g of benzyl chloride and 25 ml of the organic solution of acetophenone containing the cobalt carbonyl catalyst and recovered in Example 2 to form a reaction mixture. The reaction and subsequent processing of the reaction mixture were performed in substantially the same manner as in Example 3. The yields of phenyl pyruvic acid and phenyl acetic acid were 74.2% and 14.0%, respectively, of the respective theoretical values based on the amount of benzyl chloride.

Provenance & Evidence