Dimethoxymethane → HCID 20188673, compound

Participants

Reaction Steps

The preparation of chelators where R8 and R9 are part of a quinoline ring and W=OH begins, for example, with 2-methyl-6-methoxy-8-nitroquinoline. The methoxy group could be cleaved with BBr3 or hot HI to yield a 6-hydroxy group, which could then be protected by reaction with dimethoxymethane under acid catalysis to yield 2-methyl-6-methoxymethyloxy-8-nitroquinoline. This can be used as starting material for the synthesis outlined above for 2-methyl-6-W-8-nitroquinoline, leading to chelators with W=OCH2OCH3. Mild acid hydrolysis of this compound gives chelators with W=OH.

Provenance & Evidence