Hydromorphone Hydrochloride → Hydromorphone

HRID 1789628Notes

Reaction equation

HRID 1789628 reaction equation
[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3=[CH:8][CH:9]=[C:10]([OH:21])[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=43)[CH2:4][CH2:3]1)=[O:15].Cl>O.[O-2].[O-2].[Ti+4]>[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3=[CH:8][CH:9]=[C:10]([OH:21])[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=43)[CH2:4][CH2:3]1)=[O:15]

Participants

4

Reactant 1

HCID 5462347Hydromorphone Hydrochloride

Product 1

HCID 5284570Hydromorphone

Reagents, catalysts & solvents 2

HCID 162651Titanium oxide (Ti3O)CatalystHCID 962WaterSolvent

Procedure

Drug Loading. Hydromorphone beads were prepared by dissolving hydromorphone HCl in water, adding Opadry Y-5-1442, light pink (a product commercially available from Colorcon, West Point, PA, which contains hydroxypropyl methylcellulose, hydroxypropyl cellulose, titanium dioxide, polyethylene glycol and D&C Red No. 30 aluminum lake) and mixing for about 1 hour to obtain a 20% w/w suspension. This suspension was then sprayed onto Nu-Pareil 18/20 mesh beads using a Wurster insert.

Workup

  1. additionadding Opadry Y-5-1442
  2. additionmixing for about 1 hour
  3. customto obtain a 20% w/w suspension

Sources & evidence

ORD record
ord-d17b1f7473d642968236dadee8d1d0e6
Source dataset
uspto-grants-2006_07
Patent number
US07070806B2

Reaction notes

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