Sodium Hydroxide → HCID 178515531, compound

HRID 1789635Notes

Reaction equation

HRID 1789635 reaction equation
[OH-].[Na+].[C:3]([NH:6][C:7]1[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O)(=[O:5])[CH3:4]>C(O)C>[OH:5][C:3]1[CH:4]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]2[C:7](=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 97474Acetamide, N-(2-benzoylphenyl)-

Product 1

HCID 178515531HCID 178515531, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium hydroxide (5 M, 1.8 g, 43.9 mmol) was added to a mixture of 2-acetamidobenzophenone (10.5 g, 43.9 mmol) in ethanol (439 mL). The mixture was heated to reflux for 3 hours, then cooled to room temperature and concentrated. Water and methylene chloride were added while stirring to form a white precipitate. The solid was collected by vacuum filtration and washed with methylene chloride to yield 2-hydroxy-4-phenylquinoline.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 3 hours
  3. concentrationconcentrated
  4. additionWater and methylene chloride were added
  5. customto form a white precipitate
  6. filtrationThe solid was collected by vacuum filtration
  7. washwashed with methylene chloride

Sources & evidence

ORD record
ord-c597b0d917254b1ebe98619b8d525b87
Source dataset
uspto-grants-2006_07
Patent number
US07070868B2

Reaction notes

Loading…