反应详情

A solution of Oxone® (0.54 g, 0.88 mmol) in H2O (2 mL) was added to a 0° C. solution of 4-[(2-methylthio-ethyl)-(4-fluoro-benzyl)-amino]-N-ethyl-benzenesulfonamide (0.13 g, 0.34 mmol) in MeOH (8 mL) resulting in an immediate precipitate. After 1 h, the mixture was partitioned between CH2Cl2 and H2O. The aqueous layer was extracted with CH2Cl2 (2×). The combined organic layer was dried (Na2SO4), filtered, and evaporated in vacuo to afford 0.14 g (100%) of 4-[(2-methylsulfonyl-ethyl)-(4-fluoro-benzyl)-amino]-N-ethyl-benzenesulfonamide as a pale glass; (m+H)+ 415.

1. customresulting in an immediate precipitate
2. customthe mixture was partitioned between CH2Cl2 and H2O
3. extractionThe aqueous layer was extracted with CH2Cl2 (2×)
4. dry with materialThe combined organic layer was dried (Na2SO4)
5. filtrationfiltered
6. customevaporated in vacuo