HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 4-{2-[(3-Chloro-2-pyrazinyl)oxy]ethoxy}-1,3-benzoxazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,3-Dichloropyrazine | HCID 78575 | — |
| Reactant | 4-(2-Hydroxyethoxy)-2-amino-1,3-benzoxazol | HCID 22036460 | — |
| Product | 4-{2-[(3-Chloro-2-pyrazinyl)oxy]ethoxy}-1,3-benzoxazol-2-amine | HCID 53986732 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 4, Step 1, except that 4 equiv of both NaH and 2,3-dichloropyrazine were used, starting from the product of Step 1. The reaction temperature was 90° C. The crude product was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071180B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-79616e307bb14938ae98eb0606b016dc |
| Source note | uspto-grants-2006_07 |