3-Aminopyrrolidine → HCID 22036446, compound

HRID 1789676Notes

Reaction equation

HRID 1789676 reaction equation
Cl[C:2]1[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:6][CH:5]=[CH:4][N:3]=1.[NH2:18][CH:19]1[CH2:23][CH2:22][NH:21][CH2:20]1>>[NH2:18][CH:19]1[CH2:23][CH2:22][N:21]([C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:20]1

Participants

3

Reactant 2

HCID 1644013-AminopyrrolidineHCID 22036365HCID 22036365, compound

Product 1

HCID 22036446HCID 22036446, compound

Procedure

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-(2-phenoxyethoxy)pyrazine (150 mg, 0.60 mmol; from Example 1, Step 1) and 3-aminopyrrolidine (270 mg, 3.13 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 121 mg (67%) of the title product. Anal. (C16H19N4O2) C, H; N: calcd, 18.65; found, 18.0.

Workup

  1. extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record
ord-878084f32b84467d9e14f8ec423f47c2
Source dataset
uspto-grants-2006_07
Patent number
US07071180B2

Reaction notes

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