Hexahydro-1,4-diazepine → HCID 22036250, compound

HRID 1789679Notes

Reaction equation

HRID 1789679 reaction equation
Cl[C:2]1[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:6][CH:5]=[CH:4][N:3]=1.[NH:18]1[CH2:24][CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[N:18]1([C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:24][CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 22036365HCID 22036365, compound

Product 1

HCID 22036250HCID 22036250, compound

Procedure

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-(2-phenoxyethoxy)pyrazine (150 mg, 0.60 mmol; from Example 1, Step 1) and homopiperazine (250 mg, 2.5 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 141 mg (75%) of the title product. Anal. (C17H22N4O2.0.35EtOAc) C, H, N.

Workup

  1. extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record
ord-9057f530008443ccaf62eebd59f6579c
Source dataset
uspto-grants-2006_07
Patent number
US07071180B2

Reaction notes

Loading…