Hexahydro-1,4-diazepine → HCID 22036455, compound

HRID 1789680Notes

Reaction equation

HRID 1789680 reaction equation
Cl[C:2]1[C:7]([O:8][CH2:9][CH:10]2[O:15][C:14]3[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=3[O:12][CH2:11]2)=[N:6][CH:5]=[CH:4][N:3]=1.[NH:20]1[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[N:20]1([C:2]2[C:7]([O:8][CH2:9][CH:10]3[O:15][C:14]4[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=4[O:12][CH2:11]3)=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 22036545HCID 22036545, compound

Product 1

HCID 22036455HCID 22036455, compound

Procedure

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-(2,3-dihydro-1,4-benzodioxin-2-ylmethoxy)pyrazine* (150 mg, 0.54 mmol) and homopiperazine (266 mg, 2.66 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 105 mg (57%) of the title product. Anal. (C18H24N4O3) H, N; C: calcd, 63.14; found, 62.70.

Workup

  1. extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record
ord-f5d9959aa2d04904a8ccfb486b67a822
Source dataset
uspto-grants-2006_07
Patent number
US07071180B2

Reaction notes

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