Tert-butyl 4-hydroxypiperidine-1-carboxylate → HCID 22036490, compound

HRID 1789698Notes

Reaction equation

HRID 1789698 reaction equation
Cl[C:2]1[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:6][CH:5]=[CH:4][N:3]=1.C([N:25]1[CH2:30][CH2:29][CH:28]([OH:31])[CH2:27][CH2:26]1)(OC(C)(C)C)=O>>[NH:25]1[CH2:30][CH2:29][CH:28]([O:31][C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 22036365HCID 22036365, compound

Product 1

HCID 22036490HCID 22036490, compoundYield 35.5%

Procedure

The title compound was prepared according to the procedure described in Example 49 starting from 2-chloro-3-(2-phenoxyethoxy)pyrazine (250 mg, 1.00 mmol; from Example 1, Step 1) and N-Boc-4-hydroxypiperidine (234 mg, 1.16 mmol) to give 112 mg (35%) of the title product. HRMS m/z calcd for C17H23N3O3(M)* 315.1583, found 315.1570.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-58e76195f9b0407fb1650a8765693ea1
Source dataset
uspto-grants-2006_07
Patent number
US07071180B2

Reaction notes

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