HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-CHLORO-3-PIPERAZIN-1-YL-QUINOXALINE → 2-[2-(5-Pyrimidinyloxy)ethoxy]-3-(1-piperazinyl)quinoxaline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-CHLORO-3-PIPERAZIN-1-YL-QUINOXALINE | HCID 3846837 | — |
| Reactant | 2-(Pyrimidin-5-yloxy)ethanol | HCID 22036262 | — |
| Product | 2-[2-(5-Pyrimidinyloxy)ethoxy]-3-(1-piperazinyl)quinoxaline | HCID 22036457 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Example 162, Step 2, starting from 2-chloro-3-(1-piperazinyl)quinoxaline (0.66 g, 2.65 mmol; from is Example 162, Step 1) and 2-(5-pyrimidinyloxy)ethanol (0.45 g, 3.20 mmol). Yield 0.55 g (59%); mp 115-117° C.; HRMS m/z calcd for C18H20N6O2 (M)+352.1648, found 352.1654. Anal. (C18H20N6O2) C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071180B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-ea419a2d02d941aeb1f9de96a3ac83be |
| Source note | uspto-grants-2006_07 |